NEW ALDOL TYPE REACTION
نویسندگان
چکیده
منابع مشابه
A tandem non-aldol aldol Mukaiyama aldol reaction.
[reaction: see text] A new one-pot tandem aldol process is described in which a secondary epoxy silyl ether is converted into the 1,5-bis-silyloxy-3-alkanone in good yield. Thus, treatment of the epoxy silyl ether 8 with TBSOTf and base affords the silyl enol ether 9 via non-aldol aldol rearrangement and addition of benzaldehyde and TBSOTf gives the ketone 10 with 4:1 syn selectivity. The diast...
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Cesium fluoride catalyzed direct cyanomethylation of various isatins by using trimethylsilyl acetonitrile (TMSAN) as a nucleophile has been developed. The reaction has been explored for a number of isatins, with various substitutions on its aromatic ring. Further, the versatility of the reaction is demonstrated by converting the direct aldol adducts to the corresponding intermediates of natural...
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Mukaiyama s classic catalytic asymmetric aldol reaction with enolsilanes has been improved upon over the years; now new approaches to the reaction have been developed. Those reviewed here are the use of new transition metal based catalysts for the aldol reaction using silyl enolates, the use of other O-silylated nucleophiles, tin-modified or even unmodified ketones as substrates, and the use of...
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In an "aldol addition" reaction an enol or enolate of an aldehyde or ketone reacts with a second aldehyde or ketone forming a new carbon-carbon bond which makes the aldol reaction an important reaction for organic synthesis. Originally, the aldol reaction used ethanal (see below) and therefore the product contained both an aldehyde and an alcohol functional group; thus it became known as the al...
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 1973
ISSN: 0366-7022,1348-0715
DOI: 10.1246/cl.1973.1011